Name: Chicken Alfredo Lasagna Recipe
Prep time: 1 h
Cook time: 40 min
Total time: 1 h 40 min
Cuisine: Italian-American
Ingredients: 6 chicken tenders (or chicken breast); 1 tsp salt; ½ tsp pepper; 1 tsp cayenne pepper; 1 tsp garlic powder; 1 tsp Italian seasoning (or mixture of oregano, parsley, basil); 2 tbsp olive oil; 5 tbsp unsalted butter; ½ medium onion, finely chopped; 1 tbsp minced garlic; 1 tsp salt; ½ tsp pepper; 1 tsp chili flakes; 1 tsp Italian seasoning; 5 tbsp all-purpose flour; 2 cups whole milk; 1 cup heavy cream; 1 cup grated Parmesan cheese (freshly grated); 2 cups chopped spinach; 14-15 lasagna sheets (about one pack); 3-4 cups shredded mozzarella cheese; Freshly chopped parsley for garnish

If you’re looking for the ultimate comfort food that combines creamy decadence with layers of cheesy goodness, you’re going to absolutely love this Chicken Alfredo Lasagna Recipe. I promise, this dish is fan-freaking-tastic—creamy Alfredo sauce, tender seasoned chicken, fresh spinach, and gooey mozzarella all baked into perfect layers of lasagna. When I first tried this recipe, it instantly became a family favorite, and I can’t wait for you to try it too.

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Why You’ll Love This Recipe

Creamy and Flavorful: The combination of homemade spinach Alfredo sauce and perfectly seasoned chicken creates an irresistible depth of flavor.
Use of Fresh Ingredients: Using fresh spinach and freshly grated Parmesan really takes this lasagna from ordinary to extraordinary.
Family-Friendly Appeal: Whether you’re feeding kids or adults, this recipe satisfies all tastes and cravings.
Perfect Make-Ahead Meal: This dish is excellent for prepping ahead and even freezing, making it a smart go-to for busy weeks.

The image shows a glass baking dish filled with a lasagna that has several visible layers. The bottom layer is a red tomato sauce with some herbs, topped by a smooth creamy white cheese layer. Above that, there are pasta sheets with a beige color and wavy edges, followed by more tomato sauce and cheese layers. The top layer is golden brown melted cheese sprinkled with small green parsley pieces. The dish rests on a white marbled surface with a dark blue striped cloth in the background and a white pot with green plants nearby. Photo taken with an iphone --ar 2:3 --v 7 - Chicken Alfredo Lasagna, creamy chicken lasagna, cheesy Alfredo lasagna, baked chicken pasta, easy comfort food recipe

Ingredients You’ll Need

Every ingredient here plays a role in making this Chicken Alfredo Lasagna Recipe truly shine. From juicy chicken tenders seasoned just right to a luscious homemade Alfredo sauce kissed with spinach—these ingredients marry beautifully. If possible, use freshly grated Parmesan cheese and fresh spinach to elevate the dish even more.

Flat lay of fresh raw chicken tenders, a neat pile of uncooked flat rectangular lasagna sheets, a small white bowl of bright green chopped spinach, a small white bowl filled with freshly grated pale yellow Parmesan cheese, a small white bowl containing shredded white mozzarella cheese, a few whole uncracked brown eggs, a small white bowl of golden olive oil, a small white bowl with peeled minced garlic, a small white bowl of finely chopped white onion, a small white bowl of creamy whole milk, a small white bowl of thick heavy cream, a few sprigs of fresh green parsley, fresh cracked black peppercorns scattered artistically, coarse sea salt crystals sprinkled tastefully, red chili flakes in a small white bowl placed neatly, a small white bowl holding pale yellow unsalted butter cubes, delicate dried Italian herb leaves arranged carefully, all ingredients arranged with perfect symmetry on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997 - Chicken Alfredo Lasagna, creamy chicken lasagna, cheesy Alfredo lasagna, baked chicken pasta, easy comfort food recipe

Chicken tenders: These cook quickly and stay tender, making them perfect for layering in lasagna.
Seasonings (salt, pepper, cayenne, garlic powder, Italian seasoning): A combo that adds savory depth and a gentle kick without overpowering the creamy sauce.
Olive oil: For cooking the chicken—adds flavor and helps achieve a nice sear.
Unsalted butter: The base for your Alfredo sauce, lending richness and a silky texture.
Onion and garlic: Fresh aromatics that build the sauce’s flavor foundation.
Flour: To thicken the Alfredo sauce into that perfect creamy consistency.
Whole milk and heavy cream: Combine for a luscious, creamy sauce that’s not too heavy.
Parmesan cheese: Freshly grated is best for melt-in-your-mouth flavor.
Fresh spinach: Adds a vibrant color and subtle freshness that balances the richness.
Lasagna sheets: Boiled al dente for tenderness without mushiness.
Mozzarella cheese: Melts beautifully, giving you that classic cheesy pull everyone loves.
Fresh parsley: For garnish—brings a fresh herbal touch to finish the dish.

Note: You’ll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Variations

I love how versatile this Chicken Alfredo Lasagna Recipe is. Depending on your mood or what’s in season, you can easily switch things up. Don’t hesitate to personalize it—cooking is all about making flavors your own, right?

Swap the chicken: Once, I tried shredded rotisserie chicken for an even quicker version, and it was still incredible.
Add mushrooms or sun-dried tomatoes: They bring an earthy or tangy twist that pairs perfectly with the creamy sauce.
Make it vegetarian: Simply leave out the chicken and double the spinach or add roasted veggies like zucchini and bell peppers.
Use gluten-free lasagna sheets: These work great if you’re gluten-sensitive, just watch the boiling time carefully—they cook quicker.

How to Make Chicken Alfredo Lasagna Recipe

Step 1: Prepare the Lasagna Sheets

Start by boiling your lasagna sheets according to the package instructions until they’re al dente—firm but cooked through. This prevents the noodles from turning mushy in the oven later. Once done, toss them with a little olive oil immediately to keep them from sticking together. This small step saved me from a big mess more than once!

Step 2: Season and Cook the Chicken Tenders

Coat your chicken tenders evenly with salt, pepper, cayenne, garlic powder, and Italian seasoning, then drizzle with olive oil. Heat a cast iron skillet (or your favorite pan) on medium-high and sear the chicken until cooked through and lightly browned, about 5 minutes per side. Rest the tenders for 5 minutes before chopping them into bite-sized pieces. I find resting helps keep the chicken juicy and lets you scoop up all those flavorful juices that pool on the cutting board.

Step 3: Make the Spinach Alfredo Sauce

In a non-stick pan, melt butter over medium-high heat, then add finely chopped onions and sauté until soft, about 3-5 minutes. Toss in minced garlic and cook until fragrant (1-2 minutes), then stir in your seasoning spices and cook for another minute to release their flavors. Add flour and cook it for about a minute—that’ll help thicken your sauce without lumps. Gradually whisk in whole milk and heavy cream, then reduce heat to low while stirring until the sauce thickens slightly. Remember, it shouldn’t be too thick since it’ll continue to set in the oven. Turn off heat, stir in chopped spinach and freshly grated Parmesan, then taste and adjust seasoning if needed. This sauce is pure magic!

Step 4: Assemble Your Chicken Alfredo Lasagna

Spread about 2-3 tablespoons of the Alfredo sauce on the bottom of a 9×13″ baking dish to prevent sticking. Lay about 3 lasagna sheets flat—don’t layer sheets on top of one another here, as that adds bulk. Spoon a generous layer of Alfredo sauce over the noodles, scatter a third of your chopped chicken, and then top with roughly ¾ cup of shredded mozzarella cheese. Repeat these layers twice more, saving a bit of sauce and some noodles for the top. Finish by layering the last sheets of pasta, spreading the remaining sauce on top, and sprinkling the final cup of mozzarella over everything.

Step 5: Bake and Broil Your Lasagna

Here’s a pro tip I discovered: stick 6-8 toothpicks into the lasagna at various spots to act as tiny tent poles for your foil. This keeps the foil from sticking to the cheese during baking—a little trick that saves your beautiful cheesy top! Cover tightly with foil, bake at 375°F for about 40 minutes, then remove the foil and broil for 2-3 minutes until the cheese turns golden and bubbly. Let it rest for 15 minutes—you’ll thank me later when it slices beautifully and the flavors meld perfectly.

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Pro Tips for Making Chicken Alfredo Lasagna Recipe

Seasoning the Chicken Well: I find doubling the Italian seasoning helps deepen the flavor, especially with the creamy sauce.
Don’t Skip Resting the Chicken: Resting before chopping keeps the meat tender and locks in the juices for maximum flavor.
Sauce Thickness Matters: Make sure your Alfredo sauce is creamy but pourable—it should coat noodles but still spread easily.
Use Toothpicks for Foil Tenting: This simple hack prevents the cheese from sticking to foil and tearing your beautiful crust off.

How to Serve Chicken Alfredo Lasagna Recipe

Chicken Alfredo Lasagna Recipe - Serving

Garnishes

I always sprinkle freshly chopped parsley on top just before serving. Not only does it add a fresh pop of color, but its bright, herbaceous flavor balances the richness of the cheese and cream perfectly. If you want, a small dusting of extra Parmesan also never hurts!

Side Dishes

This lasagna pairs amazingly well with a simple green salad dressed with lemon vinaigrette or roasted vegetables like asparagus or Brussels sprouts. Garlic bread is obviously a classic, and who can say no to that cheesy, buttery goodness alongside this dish?

Creative Ways to Present

For dinner parties, I like to prepare individual portions in small ramekins or mini casserole dishes—baking time is shorter and guests love the personal touch. You can also top with edible flowers or drizzle a bit of truffle oil for an elegant flare that really wows.

Make Ahead and Storage

Storing Leftovers

Once cooled, I tightly cover leftover Chicken Alfredo Lasagna with foil or plastic wrap and refrigerate. It stays delicious for 3-4 days and reheats beautifully. I always recommend storing individual portions for easy grab-and-go meals.

Freezing

This recipe freezes wonderfully. After assembling (before baking), wrap tightly in foil and pop it in the freezer. When you’re ready, bake covered at 375°F for about an hour, then uncover and broil to finish, adding extra time as needed. It’s a lifesaver for busy weeks!

Reheating

I reheat leftovers covered in the oven at 350°F until warmed through, about 20 minutes, to keep it creamy and avoid drying out. Microwave works too but be sure to cover it and add a splash of cream or milk if it seems dry.

FAQs

Can I use shredded chicken instead of tenders for this Chicken Alfredo Lasagna Recipe?

Absolutely! Using pre-cooked shredded chicken like rotisserie chicken is a great shortcut and still tastes fantastic. Just make sure to season it well to keep flavor consistent throughout the lasagna.
Is it better to use fresh or frozen spinach in the recipe?

Fresh spinach works best here because it adds color and a bright flavor without adding excess water. If using frozen, thaw and squeeze out as much moisture as possible to avoid a watery sauce.
Can I make the Alfredo sauce ahead of time?

Yes! You can prepare the sauce a day in advance and simply reheat gently when ready to assemble. Just stir well and add a splash of milk if it thickened up too much overnight.
How do I prevent the lasagna from getting soggy?

Boiling the lasagna sheets al dente and not over-thickening the sauce helps a lot. Also, spreading sauce evenly and using toothpicks to tent the foil to keep cheese from sticking prevents sogginess and preserves the perfect texture.

Final Thoughts

This Chicken Alfredo Lasagna Recipe quickly became one of those dishes I turn to when I want cozy but impressive food on the table. What I love most is how it balances ease and elegance—perfect for family dinners or special occasions. If you want a dish that’ll have everyone asking for seconds (and the recipe), give this a try. Trust me, once you make it, you’ll be hooked just like my family and me!